CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.11710 | Cyclodipeptide synthase |
Domain Context
CATH Clusters
Superfamily | Cyclodipeptide synthase |
Functional Family | Cyclo(L-leucyl-L-phenylalanyl) synthase |
Enzyme Information
2.3.2.20 |
Cyclo(L-leucyl-L-phenylalanyl) synthase.
based on mapping to UniProt Q8GED7
L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) = tRNA(Leu) + tRNA(Phe) + cyclo(L-leucyl-L-phenylalanyl).
-!- The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the L-phenylalanine residue. -!- The protein, found in the bacterium Streptomyces noursei, also forms cyclo(L-phenylalanyl-L-phenylalanyl), cyclo(L-methionyl-L- phenylalanyl), cyclo(L-phenylalanyl-L-tyrosyl) and cyclo(L-methionyl- L-tyrosyl).
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UniProtKB Entries (1)
Q8GED7 |
CLPS_STRNR
Streptomyces noursei
Cyclo(L-leucyl-L-phenylalanyl) synthase
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PDB Structure
PDB | 3OQV |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis.
Nucleic Acids Res.
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