CATH Domain 3ocnA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.450	Beta-Lactamase
	3.30.450.330

Domain Context

CATH Clusters

Superfamily	3.30.450.330
Functional Family	Peptidoglycan D,D-transpeptidase FtsI

Enzyme Information

3.4.16.4

Serine-type D-Ala-D-Ala carboxypeptidase.

based on mapping to UniProt Q51504

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

Q51504

Q51504_PSEAI

Pseudomonas aeruginosa

Peptidoglycan D,D-transpeptidase FtsI

PDB Structure

PDB	3OCN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms Sainsbury, S., Bird, L., Rao, V., Shepherd, S.M., Stuart, D.I., Hunter, W.N., Owens, R.J., Ren, J. J.Mol.Biol.