CATH Domain 3ocbA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P31749

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P31749

AKT1_HUMAN

Homo sapiens

RAC-alpha serine/threonine-protein kinase

PDB Structure

PDB	3OCB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of pyrrolopyrimidine inhibitors of Akt. Blake, J.F., Kallan, N.C., Xiao, D., Xu, R., Bencsik, J.R., Skelton, N.J., Spencer, K.L., Mitchell, I.S., Woessner, R.D., Gloor, S.L., Risom, T., Gross, S.D., Martinson, M., Morales, T.H., Vigers, G.P., Brandhuber, B.J. Bioorg.Med.Chem.Lett.