CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1520 | Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
|
1.10.1520.10 | Ribonuclease III domain |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease III domain |
| Functional Family | Ribonuclease 3 |
Enzyme Information
| 3.1.26.3 |
Ribonuclease III.
based on mapping to UniProt Q9PM40
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- An endoribonuclease that cleaves double-stranded RNA molecules. -!- The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. -!- Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. -!- RNase III is involved in both rRNA processing and mRNA processing and decay.
|
UniProtKB Entries (1)
| Q9PM40 |
RNC_CAMJE
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Ribonuclease 3
|
PDB Structure
| PDB | 3O2R |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Flexibility in Region Involved in Dimer Formation of Nuclease Domain of Ribonuclase III (rnc) from Campylobacter jejuni.
TO BE PUBLISHED
|
