CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoglycerate mutase-like
Functional Family serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt Q96HS1
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

Q96HS1
PGAM5_HUMAN
Homo sapiens
Serine/threonine-protein phosphatase PGAM5, mitochondrial

PDB Structure

PDB 3O0T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.
Chaikuad, A., Filippakopoulos, P., Marcsisin, S.R., Picaud, S., Schroder, M., Sekine, S., Ichijo, H., Engen, J.R., Takeda, K., Knapp, S.
Structure