CATH Classification

Domain Context

CATH Clusters

Superfamily Uracil-DNA glycosylase-like domain
Functional Family

Enzyme Information

3.2.2.27
Uracil-DNA glycosylase.
based on mapping to UniProt P04303
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
-!- Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. -!- Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.

UniProtKB Entries (1)

P04303
UNG_VACCW
Vaccinia virus WR
Uracil-DNA glycosylase

PDB Structure

PDB 3NT7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Vaccinia virus D4 mutants defective in processive DNA synthesis retain binding to A20 and DNA.
Druck Shudofsky, A.M., Silverman, J.E., Chattopadhyay, D., Ricciardi, R.P.
J.Virol.