CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.20 | Single Sheet |
|
2.20.25 | N-terminal domain of TfIIb |
|
2.20.25.160 |
Domain Context
CATH Clusters
| Superfamily | 2.20.25.160 |
| Functional Family | Aspartoacylase |
Enzyme Information
| 3.5.1.114 |
N-acyl-aromatic-L-amino acid amidohydrolase.
based on mapping to UniProt Q91XE4
(1) An N-acyl-aromatic-L-amino acid + H(2)O = an aromatic-L-amino acid + a carboxylate. (2) An N-acetyl-L-cysteine-S-conjugate + H(2)O = an L-cysteine-S- conjugate + acetate.
-!- This enzyme is found in animals and is involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). -!- It preferentially deacetylates N(alpha)-acetylated aromatic amino acids and mercapturic acids (S-conjugates of N-acetyl-L-cysteine) that are usually not deacetylated by EC 3.5.1.14. -!- Some bacterial aminoacylases demonstrate substrate specificity for both EC 3.5.1.14 and EC 3.5.1.114. -!- Cf. EC 3.5.1.14 and EC 3.5.1.15.
|
UniProtKB Entries (1)
| Q91XE4 |
ACY3_MOUSE
Mus musculus
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
|
PDB Structure
| PDB | 3NH8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of aminoacylase 3 in complex with acetylated substrates.
Proc.Natl.Acad.Sci.USA
|
