CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family

Enzyme Information

3.6.1.23
dUTP diphosphatase.
based on mapping to UniProt Q8ZNF5
dUTP + H(2)O = dUMP + diphosphate.
3.6.1.9
Nucleotide diphosphatase.
based on mapping to UniProt Q8ZNF5
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.
-!- The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. -!- In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA. -!- Formerly EC 3.6.1.19.
3.6.1.-
In phosphorus-containing anhydrides.
based on mapping to UniProt Q8ZNF5
3.6.1.12
dCTP diphosphatase.
based on mapping to UniProt Q8ZNF5
dCTP + H(2)O = dCMP + diphosphate.
-!- Also hydrolyzes dCDP to dCMP and phosphate.

UniProtKB Entries (1)

Q8ZNF5
NUDI_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Nucleoside triphosphatase NudI

PDB Structure

PDB 3N77
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of Idp01880, putative NTP pyrophosphohydrolase of Salmonella typhimurium LT2
Frydrysiak, J., Cooper, D.R., Derewenda, U., Derewenda, Z.S.
To be Published