CATH Domain 3n5kA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1110	Calcium-transporting ATPase, transmembrane domain
	1.20.1110.10	Calcium-transporting ATPase, transmembrane domain

Domain Context

CATH Clusters

Superfamily	Calcium-transporting ATPase, transmembrane domain
Functional Family	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Enzyme Information

7.2.2.10

P-type Ca(2+) transporter.

based on mapping to UniProt P04191

ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).

-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria. -!- The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolyzed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolyzed. -!- In muscle cells Ca(2+) is transported from the cytosol into the sarcoplasmic reticulum. -!- Formerly EC 3.6.1.38 and EC 3.6.3.8.

UniProtKB Entries (1)

P04191

AT2A1_RABIT

Oryctolagus cuniculus

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

PDB Structure

PDB	3N5K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Ion pathways in the sarcoplasmic reticulum Ca2+-ATPase. Bublitz, M., Musgaard, M., Poulsen, H., Thogersen, L., Olesen, C., Schiott, B., Morth, J.P., Moller, J.V., Nissen, P. J.Biol.Chem.