CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.340 | Endonuclease III; domain 1 |
|
1.10.340.30 | Hypothetical protein; domain 2 |
Domain Context
CATH Clusters
| Superfamily | Hypothetical protein; domain 2 |
| Functional Family |
Enzyme Information
| 4.2.99.18 |
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt Q9X2E1
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
|
| 3.2.2.- |
Hydrolyzing N-glycosyl compounds.
based on mapping to UniProt Q9X2E1
|
UniProtKB Entries (1)
| Q9X2E1 |
OGG1_THEMA
Thermotoga maritima MSB8
Probable N-glycosylase/DNA lyase
|
PDB Structure
| PDB | 3N0U |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritima
To be Published
|
