CATH Domain 3mqeA02

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.640	Myeloperoxidase, subunit C
	1.10.640.10	Haem peroxidase domain superfamily, animal type

Superfamily	Haem peroxidase domain superfamily, animal type
Functional Family	Prostaglandin G/H synthase 2

1.14.99.1

Prostaglandin-endoperoxide synthase.

based on mapping to UniProt Q05769

Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.

-!- Acts both as a dioxygenase and as a peroxidase.

PGH2_MOUSE

Mus musculus

Prostaglandin G/H synthase 2

PDB	3MQE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life. Wang, J.L., Limburg, D., Graneto, M.J., Springer, J., Hamper, J.R., Liao, S., Pawlitz, J.L., Kurumbail, R.G., Maziasz, T., Talley, J.J., Kiefer, J.R., Carter, J. Bioorg.Med.Chem.Lett.