CATH Domain 3mpmA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P06239

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06239

LCK_HUMAN

Homo sapiens

Tyrosine-protein kinase Lck

PDB Structure

PDB	3MPM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck. Gommermann, N., Buehlmayer, P., von Matt, A., Breitenstein, W., Masuya, K., Pirard, B., Furet, P., Cowan-Jacob, S.W., Weckbecker, G. Bioorg.Med.Chem.Lett.