CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.140 | Butyryl-CoA Dehydrogenase, subunit A; domain 3 |
|
1.20.140.10 | Butyryl-CoA Dehydrogenase, subunit A, domain 3 |
Domain Context
CATH Clusters
| Superfamily | Butyryl-CoA Dehydrogenase, subunit A, domain 3 |
| Functional Family | Acyl-CoA dehydrogenase |
Enzyme Information
| 1.3.99.32 |
Glutaryl-CoA dehydrogenase (acceptor).
based on mapping to UniProt C3UVB0
Glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor.
-!- The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). -!- The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.
|
UniProtKB Entries (1)
| C3UVB0 |
ACD_DESML
Desulfococcus multivorans
Glutaryl-CoA dehydrogenase
|
PDB Structure
| PDB | 3MPJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases.
Biochemistry
|