CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.98 | Beta-galactosidase; Chain A, domain 5 |
|
2.70.98.20 | Copper amine oxidase, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Copper amine oxidase, catalytic domain |
| Functional Family | Amine oxidase |
Enzyme Information
| 1.4.3.22 |
Diamine oxidase.
based on mapping to UniProt P19801
Histamine + H(2)O + O(2) = (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 but unlike EC 1.4.3.4, they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- Formerly EC 1.4.3.6.
|
UniProtKB Entries (1)
| P19801 |
AOC1_HUMAN
Homo sapiens
Amiloride-sensitive amine oxidase [copper-containing]
|
PDB Structure
| PDB | 3MPH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Correlation of active site metal content in human diamine oxidase with trihydroxyphenylalanine quinone cofactor biogenesis
Biochemistry
|
