CATH Domain 3mdfA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.330	RRM (RNA recognition motif) domain

Domain Context

CATH Clusters

Superfamily	3.30.70.330
Functional Family

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q9UNP9

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q9UNP9

PPIE_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase E

PDB Structure

PDB	3MDF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. Hom, R.A., Chang, P.Y., Roy, S., Musselman, C.A., Glass, K.C., Selezneva, A.I., Gozani, O., Ismagilov, R.F., Cleary, M.L., Kutateladze, T.G. J.Mol.Biol.