CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family |
Enzyme Information
| 2.1.1.219 |
tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase.
based on mapping to UniProt Q9V1J7
2 S-adenosyl-L-methionine + adenine(57)/adenine(58) in tRNA = 2 S-adenosyl-L-homocysteine + N(1)-methyladenine(57)/N(1)- methyladenine(58) in tRNA.
-!- The enzyme catalyzes the formation of N(1)-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs (e.g. tRNA(Asp)). -!- Methyladenosine at position 57 is an obligatory intermediate for the synthesis of methylinosine, which is commonly found at position 57 of archaeal tRNAs. -!- Formerly EC 2.1.1.36.
|
UniProtKB Entries (1)
| Q9V1J7 |
TRMI_PYRAB
Pyrococcus abyssi GE5
TRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI
|
PDB Structure
| PDB | 3MB5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase.
Nucleic Acids Res.
|
