CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.10 | Roll | |
3.10.330 | Vcp-like ATPase; Chain A, domain 2 | |
3.10.330.20 |
Domain Context
CATH Clusters
Superfamily | 3.10.330.20 |
Functional Family | tRNA (Adenine(58)-N(1))-methyltransferase, mitochondrial isoform X1 |
Enzyme Information
2.1.1.219 |
tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase.
based on mapping to UniProt Q9V1J7
2 S-adenosyl-L-methionine + adenine(57)/adenine(58) in tRNA = 2 S-adenosyl-L-homocysteine + N(1)-methyladenine(57)/N(1)- methyladenine(58) in tRNA.
-!- The enzyme catalyzes the formation of N(1)-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs (e.g. tRNA(Asp)). -!- Methyladenosine at position 57 is an obligatory intermediate for the synthesis of methylinosine, which is commonly found at position 57 of archaeal tRNAs. -!- Formerly EC 2.1.1.36.
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UniProtKB Entries (1)
Q9V1J7 |
TRMI_PYRAB
Pyrococcus abyssi GE5
TRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI
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PDB Structure
PDB | 3MB5 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase.
Nucleic Acids Res.
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