CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.430 | Dihydrofolate Reductase, subunit A | |
3.40.430.10 | Dihydrofolate Reductase, subunit A |
Domain Context
CATH Clusters
Superfamily | Dihydrofolate Reductase, subunit A |
Functional Family | Dihydrofolate reductase |
Enzyme Information
1.5.1.3 |
Dihydrofolate reductase.
based on mapping to UniProt P0A017
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.
|
UniProtKB Entries (1)
P0A017 |
DYR_STAAU
Staphylococcus aureus
Dihydrofolate reductase
|
PDB Structure
PDB | 3M08 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1.
Antimicrob.Agents Chemother.
|