CATH Domain 3lxuX01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.200	Peptidase S8/S53 domain

Domain Context

CATH Clusters

Superfamily	Peptidase S8/S53 domain
Functional Family	Tripeptidyl peptidase 2

Enzyme Information

3.4.14.10

Tripeptidyl-peptidase II.

based on mapping to UniProt Q9V6K1

Release of an N-terminal tripeptide from a polypeptide.

-!- A cytosolic enzyme active at neutral pH. -!- Inhibited by diisopropyl fluorophosphate. -!- Belongs to peptidase family S8. -!- Formerly EC 3.4.14.8.

UniProtKB Entries (1)

Q9V6K1

TPP2_DROME

Drosophila melanogaster

Tripeptidyl-peptidase 2

PDB Structure

PDB	3LXU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Hybrid molecular structure of the giant protease tripeptidyl peptidase II. Chuang, C.K., Rockel, B., Seyit, G., Walian, P.J., Schonegge, A.M., Peters, J., Zwart, P.H., Baumeister, W., Jap, B.K. Nat.Struct.Mol.Biol.