CATH Domain 3lxpA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P29597

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29597

TYK2_HUMAN

Homo sapiens

Non-receptor tyrosine-protein kinase TYK2

PDB Structure

PDB	3LXP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. Chrencik, J.E., Patny, A., Leung, I.K., Korniski, B., Emmons, T.L., Hall, T., Weinberg, R.A., Gormley, J.A., Williams, J.M., Day, J.E., Hirsch, J.L., Kiefer, J.R., Leone, J.W., Fischer, H.D., Sommers, C.D., Huang, H.C., Jacobsen, E.J., Tenbrink, R.E., Tomasselli, A.G., Benson, T.E. J.Mol.Biol.