CATH Domain 3lvpA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08069

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08069

IGF1R_HUMAN

Homo sapiens

Insulin-like growth factor 1 receptor

PDB Structure

PDB	3LVP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles Nemecek, C., Metz, W.A., Wentzler, S., Ding, F.X., Venot, C., Souaille, C., Dagallier, A., Maignan, S., Guilloteau, J.P., Bernard, F., Henry, A., Grapinet, S., Lesuisse, D. Chem.Biol.Drug Des.