CATH Domain 3lonA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Genome polyprotein

Enzyme Information

UniProtKB Entries (1)

Q9ELS8_9HEPC

Hepatitis C virus subtype 1a

Genome polyprotein

PDB Structure

PDB	3LON
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Candidate selection and preclinical evaluation culminating in the discovery of Narlaprevir (SCH 900518): A potent, selective and orally efficacious second generation HCV NS3 serine protease inhibitor Arasappan, A., Bennett, F., Bogen, S.L., Blackman, M., Chen, K., Hendrata, S., Huang, Y., Huelgas, R.M., Nair, L., Padilla, A.I., Pan, W., Pike, R., Pinto, P., Ruan, S., Sannigrahi, M., Velaquez, F., Vibulbhan, B., Wu, W., Yang, W., Saksena, A.K., Girijavallabhan, V., Shih, N.Y., Kong, J., Meng, T., Jin, Y., Wong, J., McNamara, P., Prongay, A., Madison, V., Piwinski, J.J., Cheng, K.C., Morrison, R., Malcolm, B., Tong, X., Ralston, R., Njoroge, F.G. To be Published