CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.200 | Phosphorylase Kinase; domain 1 | |
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
Superfamily | Phosphorylase Kinase; domain 1 |
Functional Family | Myosin heavy chain kinase A |
Enzyme Information
2.7.11.7 |
[Myosin heavy-chain] kinase.
based on mapping to UniProt P42527
ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate.
-!- The enzyme from Dictyostelium sp. (slime molds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. -!- One threonine residue in each heavy chain acts as acceptor. -!- While the enzyme from some species is activated by actin, in other cases Ca(2+)/calmodulin are required for activity. -!- Formerly EC 2.7.1.129.
|
UniProtKB Entries (1)
P42527 |
MHCKA_DICDI
Dictyostelium discoideum
Myosin heavy chain kinase A
|
PDB Structure
PDB | 3LLA |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structure of the {alpha}-Kinase Domain of Dictyostelium Myosin Heavy Chain Kinase A.
Sci.Signal.
|