CATH Domain 3lk9A04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.210	Beta Polymerase; domain 3
	3.30.210.10	DNA polymerase, thumb domain

Domain Context

CATH Clusters

Superfamily	DNA polymerase, thumb domain
Functional Family	DNA polymerase beta

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P06746 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
4.2.99.-	Other carbon-oxygen lyases. based on mapping to UniProt P06746

UniProtKB Entries (1)

DPOLB_HUMAN

Homo sapiens

DNA polymerase beta

PDB Structure

PDB	3LK9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Surya Prakash, G.K., Zibinsky, M., Upton, T.G., Kashemirov, B.A., McKenna, C.E., Oertell, K., Goodman, M.F., Batra, V.K., Pedersen, L.C., Beard, W.A., Shock, D.D., Wilson, S.H., Olah, G.A. Proc.Natl.Acad.Sci.USA