CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.390 | Collagenase (Catalytic Domain) | |
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
Superfamily | Collagenase (Catalytic Domain) |
Functional Family | Collagenase 3 |
Enzyme Information
3.4.24.65 |
Macrophage elastase.
based on mapping to UniProt P39900
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
-!- Belongs to peptidase family M10B.
|
UniProtKB Entries (1)
P39900 |
MMP12_HUMAN
Homo sapiens
Macrophage metalloelastase
|
PDB Structure
PDB | 3LK8 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Exploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinases
J.Am.Chem.Soc.
|