CATH Domain 3lgpA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	Disintegrin and metalloproteinase domain-containing protein 17

Enzyme Information

3.4.24.86

ADAM 17 endopeptidase.

based on mapping to UniProt P78536

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.

-!- In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation. -!- Belongs to peptidase family M12.

UniProtKB Entries (1)

P78536

ADA17_HUMAN

Homo sapiens

Disintegrin and metalloproteinase domain-containing protein 17

PDB Structure

PDB	3LGP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and activity relationships of tartrate-based TACE inhibitors. Li, D., Popovici-Muller, J., Belanger, D.B., Caldwell, J., Dai, C., David, M., Girijavallabhan, V.M., Lavey, B.J., Lee, J.F., Liu, Z., Mazzola, R., Rizvi, R., Rosner, K.E., Shankar, B., Spitler, J., Ting, P.C., Vaccaro, H., Yu, W., Zhou, G., Zhu, Z., Niu, X., Sun, J., Guo, Z., Orth, P., Chen, S., Kozlowski, J.A., Lundell, D.J., Madison, V., McKittrick, B., Piwinski, J.J., Shih, N.Y., Shipps, G.W., Siddiqui, M.A., Strickland, C.O. Bioorg.Med.Chem.Lett.