CATH Domain 3lfsA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt P24941

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941

CDK2_HUMAN

Homo sapiens

Cyclin-dependent kinase 2

PDB Structure

PDB	3LFS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Lesuisse, D., Dutruc-Rosset, G., Tiraboschi, G., Dreyer, M.K., Maignan, S., Chevalier, A., Halley, F., Bertrand, P., Burgevin, M.C., Quarteronet, D., Rooney, T. Bioorg.Med.Chem.Lett.