CATH Domain 3lfnA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt P24941

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941

CDK2_HUMAN

Homo sapiens

Cyclin-dependent kinase 2

PDB Structure

PDB	3LFN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Lesuisse, D., Dutruc-Rosset, G., Tiraboschi, G., Dreyer, M.K., Maignan, S., Chevalier, A., Halley, F., Bertrand, P., Burgevin, M.C., Quarteronet, D., Rooney, T. Bioorg.Med.Chem.Lett.