CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.390 | Collagenase (Catalytic Domain) | |
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
Superfamily | Collagenase (Catalytic Domain) |
Functional Family | Disintegrin and metalloproteinase domain-containing protein 17 |
Enzyme Information
3.4.24.86 |
ADAM 17 endopeptidase.
based on mapping to UniProt P78536
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
-!- In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation. -!- Belongs to peptidase family M12.
|
UniProtKB Entries (1)
P78536 |
ADA17_HUMAN
Homo sapiens
Disintegrin and metalloproteinase domain-containing protein 17
|
PDB Structure
PDB | 3LE9 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Biaryl substituted hydantoin compounds as TACE inhibitors.
Bioorg.Med.Chem.Lett.
|