CATH Domain 3ldhA02

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.110	L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
	3.90.110.10	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Superfamily	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family

1.1.1.27

L-lactate dehydrogenase.

based on mapping to UniProt P00341

(S)-lactate + NAD(+) = pyruvate + NADH.

-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

LDHA_SQUAC

Squalus acanthias

L-lactate dehydrogenase A chain

PDB	3LDH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes. White, J.L., Hackert, M.L., Buehner, M., Adams, M.J., Ford, G.C., Lentz Jr., P.J., Smiley, I.E., Steindel, S.J., Rossmann, M.G. J.Mol.Biol.