CATH Domain 3lcdA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Mast/stem cell growth factor receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P07333

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07333

CSF1R_HUMAN

Homo sapiens

Macrophage colony-stimulating factor 1 receptor

PDB Structure

PDB	3LCD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode Meyers, M.J., Pelc, M., Kamtekar, S., Day, J., Poda, G.I., Hall, M.K., Michener, M.L., Reitz, B.A., Mathis, K.J., Pierce, B.S., Parikh, M.D., Mischke, D.A., Long, S.A., Parlow, J.J., Anderson, D.R., Thorarensen, A. Bioorg.Med.Chem.Lett.