CATH Domain 3l9nA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	cAMP-dependent protein kinase catalytic subunit

Enzyme Information

2.7.11.11

cAMP-dependent protein kinase.

based on mapping to UniProt P17612

ATP + a protein = ADP + a phosphoprotein.

-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P17612

KAPCA_HUMAN

Homo sapiens

CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB	3L9N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Azole-based inhibitors of AKT/PKB for the treatment of cancer. Zeng, Q., Allen, J.G., Bourbeau, M.P., Wang, X., Yao, G., Tadesse, S., Rider, J.T., Yuan, C.C., Hong, F.T., Lee, M.R., Zhang, S., Lofgren, J.A., Freeman, D.J., Yang, S., Li, C., Tominey, E., Huang, X., Hoffman, D., Yamane, H.K., Fotsch, C., Dominguez, C., Hungate, R., Zhang, X. Bioorg.Med.Chem.Lett.