CATH Classification
Domain Context
CATH Clusters
| Superfamily | Ubiquinol cytochrome reductase, transmembrane domain |
| Functional Family | Cytochrome b-c1 complex subunit Rieske, mitochondrial |
Enzyme Information
| 7.1.1.8 |
Quinol--cytochrome-c reductase.
based on mapping to UniProt Q5ZLR5
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2).
-!- The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. -!- It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. -!- The mammalian enzyme contains cytochromes b-562, b-566 and c(1), and a 2-iron ferredoxin. -!- Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3). -!- Formerly EC 1.10.2.2.
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UniProtKB Entries (1)
| D0VX28 |
D0VX28_CHICK
Gallus gallus
Cytochrome b-c1 complex subunit 6
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PDB Structure
| PDB | 3L75 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
FAMOXADONE AND RELATED INHIBITORS BIND LIKE METHOXY ACRYLATE INHIBITORS IN THE Qo SITE OF THE BC1 COMPL AND FIX THE RIESKE IRON-SULFUR PROTEIN IN A POSITIO CLOSE TO BUT DISTINCT FROM THAT SEEN WITH STIGMATELLIN AND OTHER "DISTAL" Qo INHIBITORS.
To be Published
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