CATH Classification
Level | CATH Code | Description |
---|---|---|
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2 | Mainly Beta |
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2.60 | Sandwich |
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2.60.40 | Immunoglobulin-like |
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2.60.40.150 | C2 domain |
Domain Context
CATH Clusters
Superfamily | C2 domain |
Functional Family | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
Enzyme Information
2.7.1.153 |
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P48736
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
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2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P48736
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
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UniProtKB Entries (1)
P48736 |
PK3CG_HUMAN
Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
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PDB Structure
PDB | 3L17 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer.
J.Med.Chem.
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