CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.1440 | de novo design (two linked rop proteins) |
|
1.20.1440.370 |
Domain Context
CATH Clusters
| Superfamily | 1.20.1440.370 |
| Functional Family |
Enzyme Information
| 2.7.7.n6 |
Guanine phosphate-protein transferase.
based on mapping to UniProt Q5ZSQ3
GTP + [protein]-L-tyrosine = diphosphate + [protein]-O(4)-(5'-guanylyl)- L-tyrosine.
-!- The enzyme from Legionella also functions as EC 2.7.7.n1.
|
| 2.7.7.n1 |
Protein adenylyltransferase.
based on mapping to UniProt Q5ZSQ3
(1) ATP + [protein]-L-tyrosine = diphosphate + [protein]-O(4)- (5'-adenylyl)-L-tyrosine. (2) ATP + [protein]-L-threonine = diphosphate + [protein]-O(4)- (5'-adenylyl)-L-threonine.
|
UniProtKB Entries (2)
| Q5ZSQ3 |
DRRA_LEGPH
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Multifunctional virulence effector protein DrrA
|
| P62820 |
RAB1A_HUMAN
Homo sapiens
Ras-related protein Rab-1A
|
PDB Structure
| PDB | 3L0I |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA
Proc.Natl.Acad.Sci.USA
|
