CATH Domain 3kxoA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1050	Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
	1.20.1050.10

Domain Context

CATH Clusters

Superfamily	1.20.1050.10
Functional Family	Hematopoietic prostaglandin D synthase

Enzyme Information

2.5.1.18

Glutathione transferase.

based on mapping to UniProt O60760

RX + glutathione = HX + R-S-glutathione.

-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

5.3.99.2

Prostaglandin-D synthase.

based on mapping to UniProt O60760

(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.

-!- Brings about the opening of the epidioxy bridge.

UniProtKB Entries (1)

O60760

HPGDS_HUMAN

Homo sapiens

Hematopoietic prostaglandin D synthase

PDB Structure

PDB	3KXO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of an oral potent selective inhibitor of hematopoietic prostaglandin D synthase Carron, C.P., Trujillo, J.I., Olson, K.L., Huang, W., Hamper, B.C., Dice, T., Neal, B.E., Pelc, M.J., Day, J., Rohrer, D.C., Kiefer, J.R., Moon, J.B., Schweitzer, B.A., Blake, T.D., Turner, S.R., Woerndle, R., Case, B.L., Bono, C.P., Dilworth, V.M., Funckes-Shippy, C.L., Hood, B.L., Jerome, G.M., Kornmeier, C.M., Radabaugh, M.R., Williams, M.L., Davies, M.S., Wegner, C.D., Welsch, D.J., Abraham, W.M., Warren, C.J., Dowty, M.E., Hua, F., Zutshi, A., Yang, J.Z., Thorarensen, A. TO BE PUBLISHED