CATH Domain 3kw9A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38

Cathepsin K.

based on mapping to UniProt P43235

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235

CATK_HUMAN

Homo sapiens

Cathepsin K

PDB Structure

PDB	3KW9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Rankovic, Z., Cai, J., Kerr, J., Fradera, X., Robinson, J., Mistry, A., Hamilton, E., McGarry, G., Andrews, F., Caulfield, W., Cumming, I., Dempster, M., Waller, J., Scullion, P., Martin, I., Mitchell, A., Long, C., Baugh, M., Westwood, P., Kinghorn, E., Bruin, J., Hamilton, W., Uitdehaag, J., van Zeeland, M., Potin, D., Saniere, L., Fouquet, A., Chevallier, F., Deronzier, H., Dorleans, C., Nicolai, E. Bioorg.Med.Chem.Lett.