CATH Domain 3ktiA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.226	2-enoyl-CoA Hydratase; Chain A, domain 1
	3.90.226.10	2-enoyl-CoA Hydratase; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily	2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family	ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92

Endopeptidase Clp.

based on mapping to UniProt P80244

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).

-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

P80244

CLPP_BACSU

Bacillus subtilis subsp. subtilis str. 168

ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB	3KTI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism Lee, B.-G., Park, E.Y., Lee, K.-E., Jeon, H., Sung, K.H., Paulsen, H., Rubsamen-Schaeff, H., Brotz-Oesterhelt, H., Song, H.K. Nat.Struct.Mol.Biol.