CATH Domain 3kr3D00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.100	Insulin-like, subunit E
	1.10.100.10	Insulin-like

Domain Context

CATH Clusters

Superfamily	Insulin-like
Functional Family	Insulin-like growth factor II preproprotein

Enzyme Information

UniProtKB Entries (1)

IGF2_HUMAN

Homo sapiens

Insulin-like growth factor II

PDB Structure

PDB	3KR3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. Dransfield, D.T., Cohen, E.H., Chang, Q., Sparrow, L.G., Bentley, J.D., Dolezal, O., Xiao, X., Peat, T.S., Newman, J., Pilling, P.A., Phan, T., Priebe, I., Brierley, G.V., Kastrapeli, N., Kopacz, K., Martik, D., Wassaf, D., Rank, D., Conley, G., Huang, Y., Adams, T.E., Cosgrove, L. Mol.Cancer Ther.