CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.1270 | Trp Operon Repressor; Chain A | |
1.10.1270.20 | tRNA(m1g37)methyltransferase, domain 2 |
Domain Context
CATH Clusters
Superfamily | tRNA(m1g37)methyltransferase, domain 2 |
Functional Family |
Enzyme Information
2.1.1.228 |
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt Q2GIL5
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.
|
UniProtKB Entries (1)
Q2GIL5 |
TRMD_ANAPZ
Anaplasma phagocytophilum str. HZ
TRNA (guanine-N(1)-)-methyltransferase
|
PDB Structure
PDB | 3KNU |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of tRNA (guanine-N1)-methyltransferase from Anaplasma phagocytophilum
To be Published
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