CATH Domain 3kmcA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	Disintegrin and metalloproteinase domain-containing protein 17

Enzyme Information

3.4.24.86

ADAM 17 endopeptidase.

based on mapping to UniProt P78536

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.

-!- In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation. -!- Belongs to peptidase family M12.

UniProtKB Entries (1)

P78536

ADA17_HUMAN

Homo sapiens

Disintegrin and metalloproteinase domain-containing protein 17

PDB Structure

PDB	3KMC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors. Rosner, K.E., Guo, Z., Orth, P., Shipps, G.W., Belanger, D.B., Chan, T.Y., Curran, P.J., Dai, C., Deng, Y., Girijavallabhan, V.M., Hong, L., Lavey, B.J., Lee, J.F., Li, D., Liu, Z., Popovici-Muller, J., Ting, P.C., Vaccaro, H., Wang, L., Wang, T., Yu, W., Zhou, G., Niu, X., Sun, J., Kozlowski, J.A., Lundell, D.J., Madison, V., McKittrick, B., Piwinski, J.J., Shih, N.Y., Arshad Siddiqui, M., Strickland, C.O. Bioorg.Med.Chem.Lett.