CATH Domain 3km6A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.30	Glutaredoxin
	3.40.30.10	Glutaredoxin

Domain Context

CATH Clusters

Superfamily	Glutaredoxin
Functional Family	Glutathione S-transferase P

Enzyme Information

2.5.1.18

Glutathione transferase.

based on mapping to UniProt P09211

RX + glutathione = HX + R-S-glutathione.

-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P09211

GSTP1_HUMAN

Homo sapiens

Glutathione S-transferase P

PDB Structure

PDB	3KM6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V. Quesada-Soriano, I., Parker, L.J., Primavera, A., Wielens, J., Holien, J.K., Casas-Solvas, J.M., Vargas-Berenguel, A., Aguilera, A.M., Nuccetelli, M., Mazzetti, A.P., Lo Bello, M., Parker, M.W., Garcia-Fuentes, L. J.Mol.Recognit.