CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P00517
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P00517
KAPCA_BOVIN
Bos taurus
CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB 3KKV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of PKA with a protein Kinase B-selective inhibitor.
Lin, H., Elkins, P.A., Concha, N.O., Heerding, D., Wang, W., Nidarmarthy, S., Luengo, J.I., Nelson, R., Knick, V.B., Choudhry, A.E.
To be Published