CATH Domain 3kidU02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Urokinase-type plasminogen activator

Enzyme Information

3.4.21.73

U-plasminogen activator.

based on mapping to UniProt P00749

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00749

UROK_HUMAN

Homo sapiens

Urokinase-type plasminogen activator

PDB Structure

PDB	3KID
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator Jiang, L.-G., Yu, H.-Y., Yuan, C., Wang, J.-D., Chen, L.-Q., Meehan, E.J., Huang, Z.-X., Huang, M.-D. CHIN.J.STRUCT.CHEM.