CATH Domain 3kgaA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P49137

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P49137

MAPK2_HUMAN

Homo sapiens

MAP kinase-activated protein kinase 2

PDB Structure

PDB	3KGA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy. Velcicky, J., Feifel, R., Hawtin, S., Heng, R., Huppertz, C., Koch, G., Kroemer, M., Moebitz, H., Revesz, L., Scheufler, C., Schlapbach, A. Bioorg.Med.Chem.Lett.