CATH Domain 3kf2A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Genome polyprotein

Enzyme Information

UniProtKB Entries (1)

Q6GYR8_9HEPC

Hepacivirus C

Genome polyprotein

PDB Structure

PDB	3KF2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target Cummings, M.D., Lindberg, J.D., Lin, T.-I., de Kock, H., Lenz, O., Lilja, E., Fellander, S., Baraznenok, V., Nystrom, S., Nilsson, M., Vrang, L., Edlund, M., Rosenquist, A., Samuelsson, B., Raboisson, P., Simmen, K. Angew.Chem.Int.Ed.Engl.