CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Receptor tyrosine-protein kinase erbB-3

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P21860
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P21860
ERBB3_HUMAN
Homo sapiens
Receptor tyrosine-protein kinase erbB-3

PDB Structure

PDB 3KEX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
Jura, N., Shan, Y., Cao, X., Shaw, D.E., Kuriyan, J.
Proc.Natl.Acad.Sci.USA