CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.20 | Alpha-Beta Barrel |
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3.20.20 | TIM Barrel |
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3.20.20.80 | Glycosidases |
Domain Context
CATH Clusters
Superfamily | Glycosidases |
Functional Family | Lysosomal acid glucosylceramidase |
Enzyme Information
2.4.1.- |
Hexosyltransferases.
based on mapping to UniProt P04062
|
3.2.1.104 |
Steryl-beta-glucosidase.
based on mapping to UniProt P04062
Cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol.
-!- Acts on glucosides of cholesterol and sitosterol, but not on some related sterols such as coprostanol.
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3.2.1.45 |
Glucosylceramidase.
based on mapping to UniProt P04062
D-glucosyl-N-acylsphingosine + H(2)O = D-glucose + N-acylsphingosine.
-!- Also acts on glucosylsphingosine (cf. EC 3.2.1.62).
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UniProtKB Entries (1)
P04062 |
GLCM_HUMAN
Homo sapiens
Lysosomal acid glucosylceramidase
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PDB Structure
PDB | 3KEH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structure of Glucocerebrosidase Containing the N370S mutation: Implication on Chaperon Therapy
To be Published
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