CATH Domain 3kdtA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.565	Retinoid X Receptor
	1.10.565.10	Retinoid X Receptor

Domain Context

CATH Clusters

Superfamily	Retinoid X Receptor
Functional Family	Peroxisome proliferator-activated receptor delta

Enzyme Information

UniProtKB Entries (1)

PPARA_HUMAN

Homo sapiens

Peroxisome proliferator-activated receptor alpha

PDB Structure

PDB	3KDT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). Li, J., Kennedy, L.J., Shi, Y., Tao, S., Ye, X.Y., Chen, S.Y., Wang, Y., Hernandez, A.S., Wang, W., Devasthale, P.V., Chen, S., Lai, Z., Zhang, H., Wu, S., Smirk, R.A., Bolton, S.A., Ryono, D.E., Zhang, H., Lim, N.K., Chen, B.C., Locke, K.T., O'Malley, K.M., Zhang, L., Srivastava, R.A., Miao, B., Meyers, D.S., Monshizadegan, H., Search, D., Grimm, D., Zhang, R., Harrity, T., Kunselman, L.K., Cap, M., Kadiyala, P., Hosagrahara, V., Zhang, L., Xu, C., Li, Y.X., Muckelbauer, J.K., Chang, C., An, Y., Krystek, S.R., Blanar, M.A., Zahler, R., Mukherjee, R., Cheng, P.T., Tino, J.A. J.Med.Chem.