CATH Domain 3kcjA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.150	Divalent-metal-dependent TIM barrel enzymes

Domain Context

CATH Clusters

Superfamily	Divalent-metal-dependent TIM barrel enzymes
Functional Family	Xylose isomerase

Enzyme Information

5.3.1.5

Xylose isomerase.

based on mapping to UniProt P24300

D-xylopyranose = D-xylulose.

-!- The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. -!- The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. -!- Isomerization proceeds via a hydride-shift mechanism.

UniProtKB Entries (1)

P24300

XYLA_STRRU

Streptomyces rubiginosus

Xylose isomerase

PDB Structure

PDB	3KCJ
External Links	PDBSum Proteopedia
Method	NEUTRON DIFFRACTION
Organism
Primary Citation	Identification of the Elusive Hydronium Ion Exchanging Roles with a Proton in an Enzyme at Lower pH Values Kovalevsky, A.Y., Hanson, B.L., Mason, S.A., Yoshida, T., Fisher, S.Z., Mustyakimov, M., Forsyth, V.T., Blakeley, M.P., Keen, D.A., Langan, P. Angew.Chem.Int.Ed.Engl.